https://doi.org/10.15407/spqeo4.03.202
oSemiconductor Physics, Quantum Electronics & Optoelectronics. 2001. V. 4, N 3. P. 202-206.
PACS: 33.20.E, 87.64.J
Surface enhanced infrared absorption of nucleic acids
on gold substrate
G.I. Dovbeshko 1, V.I. Chegel 2, N.Y. Gridina 3, O.P. Repnytska 1, Y.M. Shirshov 2, V.P. Tryndiak 4, I.M. Todor 4, S.A.Zynio 2
1-Institute of Physics of National Academy of Sciences of Ukraine, Prospect Nauki 46, Kyiv, 03039, Ukraine, galyna@ukma.kiev.ua;
2-Institute of Semiconductor Physics of the National Academy of Sciences of Ukraine, Prospect Nauki 45, Kiev, 03039, Ukraine;
3-A.P. Romodanov Institute of Neurosurgery of Medical Academy of Sciences of Ukraine, 32 Manuilskogo str., Kiev-04050;
4-Kavetsky Institute o f Experimental Pathology, Oncology and Radiobiology, Vasylkivska 45, Kyiv, 03022, Ukraine.
Abstract. Data on surface enhanced infrared absorption (SEIRA) of nucleic acids deposited on the metal surface have been obtained in the experiment in FTIR reflectance mode. As metal surface, we used Au of 200-500 Е thickness on glass substrate. Roughness of Au was about 50 Е. In our experimental conditions, the enhancement factor of SEIRA was 3 to 5. We obtained different enhancement factors for different vibrations of nucleic acids. Application of this method to tumour nucleic acid gave a possibility to reveal some structural peculiarities of their sugar-phosphate backbone and those after application of anti-cancer drugs.
Keywords: surface enhanced infrared absorption (SEIRA), RNA, DNA, resistant cancer, sensitive cancer, gold substrate, FTIR reflectance, anti-cancer drugs.
Paper received 13.04.01; revised manuscript received 20.06.01; accepted for publication 13.07.01.
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